Long noncoding RNA colon cancer associated transcript-1 promotes the proliferation, migration and invasion of cervical cancer
Open Access
- 21 August 2017
- journal article
- Published by Spandidos Publications in Molecular Medicine Reports
- Vol. 16 (4), 5587-5591
- https://doi.org/10.3892/mmr.2017.7302
Abstract
Previous studies have revealed significant roles for long noncoding RNA (lncRNA) in the tumorigenesis, metastasis and invasion of various tumors, including cervical cancer. The present study aimed to investigate the potential roles of lncRNA colon cancer associated transcript 1 (CCAT1) in the metastasis and invasion of cervical cancer, and to reveal the potential underlying mechanism. The mRNA expression of lncRNA CCAT1 in cervical cancer tissue was measured using the reverse transcription‑quantitative polymerase chain reaction, and the association between lncRNA CCAT1 and the metastasis of cervical cancer was analyzed. The effects of lncRNA CCAT1 expression on HeLa cell viability, and migration and invasion were also analyzed by MTT and Transwell assays. The results demonstrated that lncRNA CCAT1 was highly expressed in the cervical cancer tissue compared with the adjacent normal tissue. High expression of lncRNA CCAT1 was positively associated with tumor size, and there was correlation between high lncRNA CCAT1 expression and a poor survival rate of cervical cancer. The cell viability, and migratory and invasive abilities were suppressed by silencing CCAT1. The results of the present study indicate that lncRNA CCAT1 was highly expressed in cervical cancer, and may serve important roles in promoting the progression and metastasis of cervical cancer.Keywords
This publication has 20 references indexed in Scilit:
- Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV plus cervical cancer via sponging miR-145Tumor Biology, 2016
- Long Noncoding RNAs in Cancer: From Function to TranslationTrends in Cancer, 2015
- Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNATumor Biology, 2015
- Long Noncoding RNAs and CancerPublished by Elsevier BV ,2015
- HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancerTumor Biology, 2014
- Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancerOncotarget, 2014
- Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: A systemic review and meta-analysisEuropean Journal Of Cancer, 2013
- Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT–PNA molecular beaconsCancer Letters, 2013
- Editorial Regulating Gene Expression at the Post-Transcriptional Level: Spotlight on RNA-Binding Proteins [Hot Topic: Proteins Involved in Post-Transcriptional Control of Gene Expression]Current Protein & Peptide Science, 2012
- Colon cancer associated transcript‐1: A novel RNA expressed in malignant and pre‐malignant human tissuesInternational Journal of Cancer, 2011