Argonaute Journeys into the Heart of RISC
- 3 September 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5689), 1409-1410
- https://doi.org/10.1126/science.1103076
Abstract
Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies ( Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.Keywords
This publication has 9 references indexed in Scilit:
- Argonaute2 Is the Catalytic Engine of Mammalian RNAiScience, 2004
- Crystal Structure of Argonaute and Its Implications for RISC Slicer ActivityScience, 2004
- siRNAs at RISCStructure, 2004
- Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAsMolecular Cell, 2004
- Regulation of heterochromatin by histone methylation and small RNAsCurrent Opinion in Cell Biology, 2004
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesisGenes & Development, 2002
- Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAiScience, 2001
- An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cellsNature, 2000