Sex Difference in the Effect of ACE-DD Genotype on the Risk of Premature Myocardial Infarction
- 1 March 2004
- journal article
- Published by SAGE Publications in Angiology
- Vol. 55 (2), 155-158
- https://doi.org/10.1177/000331970405500207
Abstract
In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.Keywords
This publication has 13 references indexed in Scilit:
- CorrespondenceAtherosclerosis, 1999
- Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart StudyCirculation, 1998
- Angiotensin-Converting Enzyme Genotypes and Risk for Myocardial Infarction in WomenJournal of the American College of Cardiology, 1998
- A Meta-analysis of the Association of the Deletion Allele of the Angiotensin-Converting Enzyme Gene With Myocardial InfarctionCirculation, 1996
- An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in menThe American Journal of Cardiology, 1995
- Association between a Deletion Polymorphism of the Angiotensin-Converting-Enzyme Gene and Left Ventricular HypertrophyThe New England Journal of Medicine, 1994
- Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits.JCI Insight, 1993
- Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial InfarctionThe New England Journal of Medicine, 1992
- PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)Nucleic Acids Research, 1992
- An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.JCI Insight, 1990