Novel, Potentially Zoonotic Paramyxoviruses from the African Straw-Colored Fruit Bat Eidolon helvum
- 1 February 2013
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 87 (3), 1348-1358
- https://doi.org/10.1128/jvi.01202-12
Abstract
Bats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. Recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in Ghana. Here, we investigate this further through virus isolation and describe two novel rubulaviruses: Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2). The viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as Tuhoko viruses, Menangle virus, and Tioman virus. We developed AchPV1- and AchPV2-specific serological assays and found evidence of infection with both viruses in Eidolon helvum across sub-Saharan Africa and on islands in the Gulf of Guinea. Longitudinal sampling of E. helvum indicates virus persistence within fruit bat populations and suggests spread of AchPVs via horizontal transmission. We also detected possible serological evidence of human infection with AchPV2 in Ghana and Tanzania. It is likely that clinically significant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Africa where health surveillance and diagnostics are poor and comorbidities, such as infection with HIV or Plasmodium sp., are common.Keywords
This publication has 39 references indexed in Scilit:
- Co-circulation of diverse paramyxoviruses in an urban African fruit bat populationJournal of General Virology, 2012
- Bats host major mammalian paramyxovirusesNature Communications, 2012
- Uncovering the fruit bat bushmeat commodity chain and the true extent of fruit bat hunting in Ghana, West AfricaBiological Conservation, 2011
- Henipavirus RNA in African BatsPLOS ONE, 2009
- Sensitive and Broadly Reactive Reverse Transcription-PCR Assays To Detect Novel ParamyxovirusesJournal of Clinical Microbiology, 2008
- Evidence of Henipavirus Infection in West African Fruit BatsPLOS ONE, 2008
- Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes ( Pteropus scapulatus )Proceedings Of The Royal Society B-Biological Sciences, 2008
- Bats: Important Reservoir Hosts of Emerging VirusesClinical Microbiology Reviews, 2006
- MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research, 2004
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994