Real‐Time Automated Detection and Quantitative Analysis of Seizures and Short‐Term Prediction of Clinical Onset
Open Access
- 1 June 1998
- Vol. 39 (6), 615-627
- https://doi.org/10.1111/j.1528-1157.1998.tb01430.x
Abstract
Summary: Purpose: We describe an algorithm for rapid realtime detection, quantitation, localization of seizures, and prediction of their clinical onset. Methods: Advanced digital signal processing techniques used in time‐frequency localization, image processing, and identification of time‐varying stochastic systems were used to develop the algorithm, which operates in generic or adaptable “modes.” The “generic mode” was tested on (a) 125 partial seizures (each contained in a 10‐min segment) involving the mesial temporal regions and recorded using depth electrodes from 16 subjects, and (b) 205 ten‐minute segments of randomly selected interictal (nonseizure) data. The performance of the algorithm was compared with expert visual analysis, the current “gold standard.” Results: The generic algorithm achieved perfect sensitivity and specificity (no false‐positive and no false‐negative detections) over the entire data set. Seizure intensity, a novel measure that seems clinically relevant, ranged between 35.7 and 6129. Detection was sufficiently rapid to allow prediction of clinical onset in 92% of seizures by a mean of 15.5 s. Conclusions: This algorithm, which was implemented with a personal computer, represents a definitive step toward rapid and accurate detection and prediction of seizures. It may also enable development of intelligent devices for automated seizure warning and treatment and stimulate new study of the dynamics of seizures and of the epileptic brain.Keywords
This publication has 34 references indexed in Scilit:
- An approach to seizure detection using an artificial neural network (ANN)Electroencephalography and Clinical Neurophysiology, 1996
- Do Chaos-Control Techniques Offer Hope for Epilepsy?Science, 1994
- Controlling chaos in the brainNature, 1994
- Chaos under controlNature, 1994
- A structure for adaptive order statistics filteringIEEE Transactions on Image Processing, 1994
- Self-Abatement of Simple Partial Epileptic SeizuresEuropean Neurology, 1991
- Comparison of algorithms for standard median filteringIEEE Transactions on Signal Processing, 1991
- Multiresolution Approximations and Wavelet Orthonormal Bases of L 2 (R)Transactions of the American Mathematical Society, 1989
- Self‐abatement of complex partial seizuresAnnals of Neurology, 1985
- Oscillation and Chaos in Physiological Control SystemsScience, 1977