Histone modifications and their role in epigenetics of atopy and allergic diseases
Open Access
- 23 May 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Allergy, Asthma & Clinical Immunology
- Vol. 14 (1), 1-16
- https://doi.org/10.1186/s13223-018-0259-4
Abstract
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of histone modifications in allergy and the mechanisms underlying this development. In addition to covering the growing interest in the contribution of histone modifications in regulating the development of allergic diseases, this review summarizes some of the evidence supporting this contribution. There are at least two levels at which the role of histone modifications is manifested. One is the regulation of cells that contribute to the allergic inflammation (T cells and macrophages) and those that participate in airway remodeling [(myo-) fibroblasts]. The other is the direct association between histone modifications and allergic phenotypes. Inhibitors of histone-modifying enzymes may potentially be used as anti-allergic drugs. Furthermore, epigenetic patterns may provide novel tools in the diagnosis of allergic disorders.Keywords
Funding Information
- German Center for Lung Research (82DZL00502/A2)
- Universities Giessen and Marburg Lung Centre
- von Behring-Röntgen-Foundation
- National Health and Medical Research Council (NHMRC) of Australia (353555, 513709)
- German Academic Exchange Service (91559386)
- HessenFonds, World University Service (WUS), the Hessen State Ministry for Higher Education, Research and the Arts
This publication has 116 references indexed in Scilit:
- Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthmaJournal of Translational Medicine, 2013
- Histone H3 phosphorylation – A versatile chromatin modification for different occasionsBiochimie, 2012
- Histone Deacetylase (HDAC) 1 Controls the Expression of Beta Defensin 1 in Human Lung Epithelial CellsPLOS ONE, 2012
- Regulation of A Disintegrin And Metalloprotease-33 Expression by Transforming Growth Factor-βAmerican Journal of Respiratory Cell and Molecular Biology, 2012
- Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymesCurrent Opinion in Structural Biology, 2011
- MYST protein acetyltransferase activity requires active site lysine autoacetylationThe EMBO Journal, 2011
- Regulation of chromatin by histone modificationsCell Research, 2011
- Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 MethylationMolecular Cell, 2010
- Diversity of degradation signals in the ubiquitin–proteasome systemNature Reviews Molecular Cell Biology, 2008
- Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylationOncogene, 2007