Hormonal regulation of LH receptor mRNA and expression in the rat ovary
- 12 November 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 274 (1-2), 181-184
- https://doi.org/10.1016/0014-5793(90)81359-v
Abstract
Agonist-induced changes in expression and mRNA levels of luteinizing hormone (LH) receptors were compared during stimulation of ovarian follicular maturation and luteinization by gonadotropic hormones. Three major species of LH receptor mRNA, 5.8, 2.6 and 2.3 kb, were present throughout differentiation and changed similarly, the 5.8 kb species being consistently more abundant than the smaller forms. The increased expression of plasma-membrane LH receptors in preovulatory follicles and luteinized ovaries and their homologous down-regulation during follicular and luteal desensitization were closely correlated with the steady-state receptor mRNA levels. The reappearance of LH receptors following desensitization during the luteal stage was preceded by an increase in mRNA levels. These studies have demonstrated that the expression of LH receptors during follicular maturation, ovulation and desensitization is related to the prevailing levels of receptor mRNA in the ovaryKeywords
This publication has 14 references indexed in Scilit:
- Isolation and characterization of two novel rat ovarian lactogen receptor cDNA speciesBiochemical and Biophysical Research Communications, 1990
- Cloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane DomainScience, 1989
- Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor FamilyScience, 1989
- Endocrine Regulation and Communicating Functions of the Leydig CellAnnual Review of Physiology, 1988
- Molecular Aspects of Hormone Action in Ovarian Follicular Development, Ovulation, and LuteinizationAnnual Review of Physiology, 1988
- Hormonal regulation of rat Leydig cell cytochrome P-45017α mRNA levels and characterization of a partial length rat P-45017α cDNABiochemical and Biophysical Research Communications, 1988
- Hormonal regulation of cytodifferentiation and intercellular communication in cultured granulosa cells.Proceedings of the National Academy of Sciences of the United States of America, 1981
- Regulation of ovarian gonadotropin receptors and LH bioactivity during the estrous cycleFEBS Letters, 1980
- Lactogenic receptor regulation in hormone-stimulated steroidogenic cellsNature, 1980
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979