Development of Monocytes, Macrophages, and Dendritic Cells
- 5 February 2010
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5966), 656-661
- https://doi.org/10.1126/science.1178331
Abstract
Development of Myeloid Immune Cells: As leukocytes develop to maturity, they proceed through an array of phenotypically distinct intermediates. For T and B lymphocyte populations, the different developmental stages, anatomical locations, and cell signals required for progression are well established. However, until recently, much less has been known about how development proceeds in the myeloid lineage, which includes monocytes, macrophages, and dendritic cells. Geissmann et al. (p. 656 ) review our current understanding of myeloid lineage development and describe the developmental pathways and cues that drive differentiation.Keywords
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