Identification and Determination of Tele-Methylhistamine in Cerebrospinal Fluid by Gas Chromatography-Mass Spectrometry
- 1 August 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (2), 461-466
- https://doi.org/10.1111/j.1471-4159.1981.tb00478.x
Abstract
The presence of tele-methylhistamine in human cerebrospinal fluid has been established. The concentration was determined with the use of deuterated tele-methylhistamine. The preparation of the deuterated standard is described. The concentration range in samples from neuropsychiatric patients was 0.1-2.5 ng/ml. The structure of the pentafluoropropionyl derivative used for gas chromatography was studied with the aid of proton nuclear magnetic resonance spectroscopy.Keywords
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