Cytotoxic Constituents of the Stem Bark of Neolitsea acuminatissima
- 7 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (3), 255-258
- https://doi.org/10.1021/np010236w
Abstract
Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.Keywords
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