The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31p magnetic resonance spectroscopy
- 31 December 1992
- journal article
- research article
- Published by Elsevier BV in International Journal of Radiation Oncology*Biology*Physics
- Vol. 22 (3), 473-476
- https://doi.org/10.1016/0360-3016(92)90856-d
Abstract
31P magnetic resonance spectroscopy has been used to compare the effects of the vasoactive agents hydralazine and flunarizine on the oxygenation of the transplantable tumors, SCCVII/Ha and 16C, and a range of spontaneous mammary tumors arising in the breeding stock in the Genetics Division at the Radiobiology Unit. The vasodilator hydralazine, previously shown to increase the radiobiological hypoxic fraction of transplantable murine tumors, increased inorganic phosphate to total phosphate (Pi/total) in SCCVII/Ha and 16C tumors. However, only two spontaneous tumors responded to this agent (2/12). The calcium antagonist flunarizine, which sensitizes the SCCVII tumor to X rays, consistent with a reduction in hypoxic fraction, reduced Pi/total in this and the 16C tumor. Further, most spontaneous tumors tested (8/10) responded to this agent, as measured by a reduction in Pi/total. These results point to fundamental differences between transplantable and spontaneously arising tumors in mice in their response to vasoactive agents.Keywords
This publication has 11 references indexed in Scilit:
- Differences in vascular response between primary and transplanted tumoursBritish Journal of Cancer, 1991
- Induction of tumour hypoxia by a vasoactive agent A combined NMR and radiobiological studyFEBS Letters, 1989
- Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069in VivoInternational Journal of Radiation Biology, 1989
- Cinnarizine and flunarizine as radiation sensitisers in two murine tumoursBritish Journal of Cancer, 1988
- Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazineBritish Journal of Cancer, 1988
- Effects of Hydralazine-Induced Vasodilation on the Energy Metabolism of Murine Tumors Studied by In Vivo31P-Nuclear Magnetic Resonance Spectroscopy1JNCI Journal of the National Cancer Institute, 1988
- Chemical modification of tumour blood flowInternational Journal of Hyperthermia, 1988
- The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: Evidence for therapeutic gainInternational Journal of Radiation Oncology*Biology*Physics, 1987
- Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in miceBritish Journal of Cancer, 1977
- Changes of Oxygen Tension in Tumours Induced by Vasoconstrictor and Vasodilator DrugsActa Radiologica, 1962