Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro
Open Access
- 15 April 2011
- Vol. 4 (4), 801-815
- https://doi.org/10.3390/ma4040801
Abstract
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.This publication has 31 references indexed in Scilit:
- Organotin Polyethers as BiomaterialsMaterials, 2009
- Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell linesBMC Cancer, 2009
- Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid – Novel anti-tuberculosis agentsJournal of Inorganic Biochemistry, 2009
- The Proteasome Is a Molecular Target of Environmental Toxic OrganotinsEnvironmental Health Perspectives, 2009
- Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9Molecular Cancer Therapeutics, 2008
- Diethylstilbestrol (DES) labeled with Auger emitters: Potential radiopharmaceutical for therapy of estrogen receptor-positive tumors and their metastases?International Journal of Radiation Biology, 2008
- Co-culture of Primary Human Mammary Fibroblasts and MCF-7 Cells as an In Vitro Breast Cancer ModelToxicological Sciences, 2004
- Organotin Compounds: Toxicokinetic AspectsDrug Metabolism Reviews, 2004
- Interaction between Herceptin® and TaxanesOncology, 2001
- Differential Effects of Tri- n -Butylstannyl Benzoates on Induction of Apoptosis in K562 and MCF-7 CellsIUBMB Life, 2000