Epidemiology and clinical presentation of respiratory syncytial virus infection in a rural area of southern Mozambique
- 1 February 2002
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 21 (2), 148-155
- https://doi.org/10.1097/00006454-200202000-00013
Abstract
Background. Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in infants throughout most of the world, but little is known about RSV infection in Africa where LRTI are among the leading causes of infant and childhood death. Methods. The study took place in a rural district hospital in southern Mozambique between October, 1998, and May, 2000. From all children (n = 5635) n = 1307) <5 years of age admitted to hospital with a LRTI, a nasopharyngeal aspirate was collected and tested for RSV by enzyme-linked immunosorbent assay (Abbott). Results. RSV infection was found in 8.6% of study infants in the outpatient department and 10.6% of admitted children with LRTI. Cases presented in predictable yearly outbreaks during the warm and rainy season. Lower respiratory tract involvement was frequent (59.7%). Cough, chest indrawing and increased respiratory rate were all independently related to RSV infection. Wheezing was infrequent. Bacterial coinfection (4.6%) and the case-fatality rate (3.4%) were low. Conclusions. There is a substantial burden of disease attributable to RSV infection in this rural African setting, with the highest incidence and severity occurring in young infants.Keywords
This publication has 24 references indexed in Scilit:
- Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1The Journal of Pediatrics, 2000
- Respiratory syncytial virus infectionThe Lancet, 1999
- Twenty Years of Outpatient Respiratory Syncytial Virus Infection: A Framework for Vaccine Efficacy TrialsPEDIATRICS, 1997
- The etiology of pneumonia in malnourished and well-nourished Gambian childrenThe Pediatric Infectious Disease Journal, 1994
- Respiratory syncytial virus illnesses in human immunodeficiency virus- and noninfected childrenThe Pediatric Infectious Disease Journal, 1993
- Respiratory syncytial virus puzzle: Clinical features, pathophysiology, treatment, and preventionThe Journal of Pediatrics, 1992
- Acute respiratory infections during the first three months of lifePediatric Emergency Care, 1990
- Viral Lower Respiratory Tract Infections in Filipino ChildrenThe Journal of Infectious Diseases, 1990