Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
Open Access
- 10 December 2009
- journal article
- case report
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 9 (1), 200
- https://doi.org/10.1186/1471-2334-9-200
Abstract
Background Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. Case presentation We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection. Conclusions Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.Keywords
This publication has 32 references indexed in Scilit:
- Post-Epidemic Chikungunya Disease on Reunion Island: Course of Rheumatic Manifestations and Associated Factors over a 15-Month PeriodPLoS Neglected Tropical Diseases, 2009
- Seroprevalence and Risk Factors of Chikungunya Virus Infection in Mayotte, Indian Ocean, 2005-2006: A Population-Based SurveyPLOS ONE, 2008
- Connective tissue metabolism in chikungunya patientsVirology Journal, 2008
- A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe DiseasePLoS Pathogens, 2008
- CD40-CD40 Ligand Interactions Promote Trafficking of CD8 + T Cells into the Brain and Protection against West Nile Virus EncephalitisJournal of Virology, 2007
- Characterization of Reemerging Chikungunya VirusPLoS Pathogens, 2007
- Human Muscle Satellite Cells as Targets of Chikungunya Virus InfectionPLOS ONE, 2007
- Hyper-IgM1 syndrome with interstitial pneumonia and diarrhea caused by coxsackievirus B4 in a 3-month-old infantAnnals of Allergy, Asthma & Immunology, 2005
- A destructive arthropathy following Chikungunya virus arthritis — a possible associationClinical Rheumatology, 1984
- An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–1953Transactions of the Royal Society of Tropical Medicine and Hygiene, 1957