Cortactin: coupling membrane dynamics to cortical actin assembly
- 1 October 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 20 (44), 6418-6434
- https://doi.org/10.1038/sj.onc.1204783
Abstract
Exposure of cells to a variety of external signals causes rapid changes in plasma membrane morphology. Plasma membrane dynamics, including membrane ruffle and microspike formation, fusion or fission of intracellular vesicles, and the spatial organization of transmembrane proteins, is directly controlled by the dynamic reorganization of the underlying actin cytoskeleton. Two members of the Rho family of small GTPases, Cdc42 and Rac, have been well established as mediators of extracellular signaling events that impact cortical actin organization. Actin-based signaling through Cdc42 and Rac ultimately results in activation of the actin-related protein (Arp) 2/3 complex, which promotes the formation of branched actin networks. In addition, the activity of both receptor and non-receptor protein tyrosine kinases along with numerous actin binding proteins works in concert with Arp2/3-mediated actin polymerization in regulating the formation of dynamic cortical actin-associated structures. In this review we discuss the structure and role of the cortical actin binding protein cortactin in Rho GTPase and tyrosine kinase signaling events, with the emphasis on the roles cortactin plays in tyrosine phosphorylation-based signal transduction, regulating cortical actin assembly, transmembrane receptor organization and membrane dynamics. We also consider how aberrant regulation of cortactin levels contributes to tumor cell invasion and metastasis.This publication has 98 references indexed in Scilit:
- Recruitment of the Arp2/3 complex and Mena for the stimulation of actin polymerization in growth cones by nerve growth factorJournal of Neuroscience Research, 2000
- Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicingJournal of Molecular Biology, 2000
- Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP FamilyBiochemical and Biophysical Research Communications, 1999
- EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survivalOncogene, 1998
- ?-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neuronsJournal of Neuroscience Research, 1997
- p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed CellsOnline Journal of Public Health Informatics, 1995
- Soluble Ligands of the αvβ4 Integrin Mediate Enhanced Tyrosine Phosphorylation of Multiple Proteins in Adherent Bovine Pulmonary Artery Endothelial CellsOnline Journal of Public Health Informatics, 1995
- Molecular Cloning and Characterization of Mouse HS1Biochemical and Biophysical Research Communications, 1995
- Invadopodia promote proteolysis of a wide variety of extracellular matrix proteinsJournal of Cellular Physiology, 1994
- Local degradation of fibronectin at sites of expression of the transforming gene product pp60srcNature, 1985