Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract ofClematis brachiataleaf in male rats
- 7 May 2010
- journal article
- research article
- Published by Informa UK Limited in Pharmaceutical Biology
- Vol. 48 (6), 682-689
- https://doi.org/10.3109/13880200903257966
Abstract
Clematis brachiata Thunb. (Ranunculaceae) is used as a folk remedy for the treatment of pain, fever and inflammatory ailments. Aqueous extract of Clematis brachiata leaf was screened for its phytochemical constituents. The anti-inflammatory investigations were carried out using carrageenan and histamine-induced edema models; acetic acid writhing, formalin-induced pain and tail immersion models were used to evaluate antinociceptive activity while a Brewer’s yeast-induced hyperthermia model was employed for the antipyretic experiment. Phytochemical screening of the extract revealed the presence of tannins, saponins, flavonoids and cardiac glycosides. The extract at 100, 200 and 400 mg/kg body weight significantly (PClematis brachiata leaves can be employed in the management of inflammation, pain and fever. These activities may be due in part to the flavonoid content of the extract.Keywords
This publication has 31 references indexed in Scilit:
- The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstrokeNeuropharmacology, 2007
- Non-volatile taste components of canned mushroomsFood Chemistry, 2006
- Anti-inflammatory, Analgesic and Antipyretic Activities of Dicliptera verticillataInternational Journal of Pharmacology, 2006
- Antiinflammatory and Analgesic Effects of Phlomis lanceolata Boiss. and Hohen. Extracts and Examination of their ComponentsInternational Journal of Pharmacology, 2005
- Aspirin and Other Cyclooxygenase Inhibitors: New Therapeutic InsightsSeminars in Vascular Medicine, 2003
- Antinociceptive and antipyretic activities of Pongamia pinnata leavesPhytotherapy Research, 2003
- Pharmacological Studies of Rhus RetinorrhaeaInternational Journal of Pharmacognosy, 1995
- Analgesic, Antipyretic and Anti-Inflammatory Properties ofEuphorbia hirtaPlanta Medica, 1991
- Antiinflammatory effect of Curcuma xanthorrhiza Roxb. and its active principles.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- The formalin test in mice: dissociation between inflammatory and non-inflammatory painPain, 1987