Sucrose-mediated translational control
Open Access
- 17 April 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Annals of Botany
- Vol. 104 (1), 1-7
- https://doi.org/10.1093/aob/mcp086
Abstract
Environmental factors greatly impact plant gene expression and concentrations of cellular metabolites such as sugars and amino acids. The changed metabolite concentrations affect the expression of many genes both transcriptionally and post-transcriptionally. Sucrose acts as a signalling molecule in the control of translation of the S1 class basic leucine zipper transcription factor (bZIP) genes. In these genes the main bZIP open reading frames (ORFs) are preceded by upstream open reading frames (uORFs). The presence of uORFs generally inhibits translation of the following ORF but can also be instrumental in specific translational control. bZIP11, a member of the S1 class bZIP genes, harbours four uORFs of which uORF2 is required for translational control in response to sucrose concentrations. This uORF encodes the Sucrose Control peptide (SC-peptide), which is evolutionarily conserved among all S1 class bZIP genes in different plant species. Arabidopsis thaliana bZIP11 and related bZIP genes seem to be important regulators of metabolism. These proteins are targets of the Snf1-related protein kinase 1 (SnRK1) KIN10 and KIN11, which are responsive to energy deprivation as well as to various stresses. In response to energy deprivation, ribosomal biogenesis is repressed to preserve cellular function and maintenance. Other key regulators of ribosomal biogenesis such as the protein kinase Target of Rapamycin (TOR) are tightly regulated in response to stress. Plants use translational control of gene expression to optimize growth and development in response to stress as well as to energy deprivation. This Botanical Briefing discusses the role of sucrose signalling in the translational control of bZIP11 and the regulation of ribosomal biogenesis in response to metabolic changes and stress conditions.Keywords
This publication has 49 references indexed in Scilit:
- Expression patterns within the Arabidopsis C/S1 bZIP transcription factor network: availability of heterodimerization partners controls gene expression during stress response and developmentPlant Molecular Biology, 2008
- Convergent energy and stress signalingTrends in Plant Science, 2008
- The Arabidopsis TOR kinase links plant growth, yield, stress resistance and mRNA translationEMBO Reports, 2007
- A central integrator of transcription networks in plant stress and energy signallingNature, 2007
- Regulatory Functions of Nuclear Hexokinase1 Complex in Glucose SignalingCell, 2006
- Combinatorial control of Arabidopsis proline dehydrogenase transcription by specific heterodimerisation of bZIP transcription factorsThe EMBO Journal, 2006
- Large-Scale Analysis of mRNA Translation States during Sucrose Starvation in Arabidopsis Cells Identifies Cell Proliferation and Chromatin Structure as Targets of Translational ControlPlant Physiology, 2006
- The Plastid Protein THYLAKOID FORMATION1 and the Plasma Membrane G-Protein GPA1 Interact in a Novel Sugar-Signaling Mechanism inArabidopsisPlant Cell, 2006
- Sugars and Circadian Regulation Make Major Contributions to the Global Regulation of Diurnal Gene Expression in ArabidopsisPlant Cell, 2005
- Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal SignalingScience, 2003