Genome‐wide association study for inhibin, luteinizing hormone, insulin‐like growth factor 1, testicular size and semen traits in bovine species
Open Access
- 19 June 2013
- Vol. 1 (4), 644-650
- https://doi.org/10.1111/j.2047-2927.2013.00101.x
Abstract
The fertility of young bulls impacts on reproduction rates, farm profit and the rate of genetic progress in beef herds. Cattle researchers and industry therefore routinely collect data on the reproductive performance of bulls. Genome-wide association studies were carried out to identify genomic regions and genes associated with reproductive traits measured during the pubertal development of Tropical Composite bulls, from 4 to 24 months of age. Data from 1 085 bulls were collected for seven traits: blood hormone levels of inhibin at 4 months (IN), luteinizing hormone following a gonadotropin releasing hormone challenge at 4 months (LH), insulin-like growth factor 1 at 6 months (IGF1), scrotal circumference at 12 months (SC), sperm motility at 18 months (MOT), percentage of normal spermatozoa at 24 months (PNS) and age at a scrotal circumference of 26 cm (AGE26, or pubertal age). Data from 729 068 single-nucleotide polymorphisms were used in the association analysis. Significant polymorphism associations were discovered for IN, IGF1, SC, AGE26 and PNS. Based on these associations, INHBE, INHBC and HELB are proposed as candidate genes for IN regulation. Polymorphisms associated with IGF1 mapped to the PLAG1 gene region, validating a reported quantitative trait locus on chromosome 14 for IGF1. The X chromosome contained most of the significant associations found for SC, AGE26 and PNS. These findings will contribute to the identification of diagnostic genetic markers and informed genomic selection strategies to assist breeding of cattle with improved fertility. Furthermore, this work provides evidence contributing to gene function annotation in the context of male fertility.Keywords
This publication has 38 references indexed in Scilit:
- Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattleAnimal Genetics, 2013
- Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattleBMC Genomic Data, 2012
- Genome-wide association studies of female reproduction in tropically adapted beef cattle1Journal of Animal Science, 2012
- Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication StressOnline Journal of Public Health Informatics, 2012
- Action Mechanism of Inhibin α-Subunit on the Development of Sertoli Cells and First Wave of Spermatogenesis in MicePLOS ONE, 2011
- Genetic Architecture of Complex Traits and Accuracy of Genomic Prediction: Coat Colour, Milk-Fat Percentage, and Type in Holstein Cattle as Contrasting Model TraitsPLoS Genetics, 2010
- Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathwaysBMC Cancer, 2010
- High-Resolution Detection of Identity by Descent in Unrelated IndividualsAmerican Journal of Human Genetics, 2010
- Development and Characterization of a High Density SNP Genotyping Assay for CattlePLOS ONE, 2009
- The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and EvolutionScience, 2009