Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
Open Access
- 4 May 2013
- journal article
- research article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 7 (6), 1336-1342
- https://doi.org/10.1111/irv.12119
Abstract
The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. Two series of hospitalized patients with laboratory‐confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009–2010 and 707 in the season 2010–2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010–2011 season than in the previous season (RR = 2·10; 95% confidence intervals CI, 1·55–2·85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR = 3·22, 95% CI, 2·15–4·83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in‐hospital death odds ratio (OR = 3·77, 95% CI, 2·30–6·18). Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.Keywords
Funding Information
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III (Ministry of Science and Innovation
- National Institute of Health Carlos III)
- Programme of Research on Influenza A/H1N1 (GR09/0030)
- Agency for the Management of Grants for University Research (AGAUR, 2009/SGR 42)
This publication has 26 references indexed in Scilit:
- Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009–2010 in the UKThorax, 2012
- Geographic Distribution and Risk Factors of the Initial Adult Hospitalized Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in Mainland ChinaPLOS ONE, 2011
- Distinguishing Characteristics between Pandemic 2009–2010 Influenza A (H1N1) and Other Viruses in Patients Hospitalized with Respiratory IllnessPLOS ONE, 2011
- Is influenza A(H1N1) pneumonia more severe than other community-acquired pneumonias? Results of the GiViTI survey of 155 Italian ICUsIntensive Care Medicine, 2011
- Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenzaCMAJ : Canadian Medical Association Journal, 2010
- Hospitalizations for Pandemic (H1N1) 2009 among Maori and Pacific Islanders, New ZealandEmerging Infectious Diseases, 2010
- Clinical and Epidemiologic Characteristics of an Outbreak of Novel H1N1 (Swine Origin) Influenza A Virus among United States Military BeneficiariesClinical Infectious Diseases, 2009
- Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in MexicoThe New England Journal of Medicine, 2009
- Severe Respiratory Disease Concurrent with the Circulation of H1N1 InfluenzaThe New England Journal of Medicine, 2009
- The Signature Features of Influenza Pandemics — Implications for PolicyThe New England Journal of Medicine, 2009