The effect of cryotherapy on total antioxidative capacity in patients with active seropositive rheumatoid arthritis
- 11 July 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Rheumatology International
- Vol. 37 (9), 1481-1487
- https://doi.org/10.1007/s00296-017-3771-9
Abstract
Patients with rheumatoid arthritis (RA) have increased oxidative stress, decreased antioxidant levels, and impaired antioxidant capacity. Cold treatments are used to relieve joint inflammation and pain. Therefore, we measured the effect of cold treatments on the antioxidative capacity of RA patients with active disease. Sixty patients were randomized to (1) whole body cryotherapy at −110 °C, (2) whole body cryotherapy at −60 °C, or (3) local cryotherapy. Each treatment was given three times daily for 7 consecutive days in addition to the conventional rehabilitation. Blinded rheumatologist evaluated disease activity before the first and after the last cryotherapy. We collected plasma samples daily immediately before the first and after the second cryotherapy and measured total peroxyl radical trapping antioxidant capacity of plasma (TRAP), which reflects global combined antioxidant capacity of all individual antioxidants in plasma. Baseline morning TRAP levels (mean, 95% CI), adjusted for age, body mass index, disease activity, and dose of prednisolone, were 1244 (1098–1391) µM/l in the local cryotherapy, 1133 (1022–1245) µM/l in the cryotherapy at −60 °C, and 989 (895–1082) µM/l in the cryotherapy at −110 °C groups (p = 0.006). After the first treatment, there was a rise in 1-h TRAP of 14.2 (−4.2 to 32.6) µM/l, 16.1 (−7.4 to 39.6) µM/l, and 23.6 (4.1–43.2) µM/l, respectively. The increase was significant in the whole-body cryotherapy −110 °C group (p < 0.001) but not significant between the groups (p = 0.78). When analyzed for the whole week, the daily morning TRAP values differed significantly between the treatment groups (p = 0.021), but there was no significant change within each treatment group. Whole-body cryotherapy at −110 °C induced a short-term increase in TRAP during the first treatment session with but not during other treatment modalities. The effect was short and the cold treatments did not cause a significant oxidative stress or adaptation during 1 week.Keywords
Funding Information
- Finnish Social Insurance Institution
This publication has 33 references indexed in Scilit:
- The effect of infliximab on oxidative stress in chronic inflammatory joint diseaseCurrent Medical Research and Opinion, 2007
- Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilageScandinavian Journal of Rheumatology, 2005
- Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activityFree Radical Research, 2005
- Acute and long?term effects of winter swimming and whole?body cryotherapy on plasma antioxidative capacity in healthy womenScandinavian Journal of Clinical and Laboratory Investigation, 2005
- Die Bedeutung der Ganzkörperkältetherapie im Rahmen der Rehabilitation bei Patienten mit rheumatischen Erkrankungen - - Ergebnisse einer Pilotstudie -Die Rehabilitation, 2000
- Improved antioxidative protection in winter swimmersQJM: An International Journal of Medicine, 1999
- Is there an unidentified defence mechanism against infection in human plasma?FEBS Letters, 1996
- Effect of reactive oxygen species on the biosynthesis and structure of newly synthesized proteoglycansFree Radical Biology & Medicine, 1994
- Control of Oxidative Damage in Rheumatoid Arthritis By Gold(I)-Thiolate DrugsFree Radical Research Communications, 1990
- Effect of oxygen‐derived free radicals on hyaluronic acidArthritis & Rheumatism, 1980