Adoptive T‐cell therapy for fungal infections in haematology patients
Open Access
- 14 August 2015
- journal article
- review article
- Published by Wiley in Clinical & Translational Immunology
- Vol. 4 (8), e40
- https://doi.org/10.1038/cti.2015.16
Abstract
The prolonged immune deficiency resulting from haematopoietic stem cell transplant and chemotherapy predisposes to a high risk of invasive fungal infections. Despite the recent advances in molecular diagnostic testing, early initiation of pre‐emptive antifungal therapy and the use of combination pharmacotherapy, mortality from invasive mould infections remain high among recipients of allogeneic stem cell transplant. The increasing incidences of previously rare and drug‐resistant strains of fungi present a further clinical challenge. Therefore, there is a need for novel strategies to combat fungal infections in the immunocompromised. Adoptive therapy using in vitro‐expanded fungus‐specific CD4 cells of the Th‐1 type has shown clinical efficacy in murine studies and in a small human clinical study. Several techniques for the isolation and expansion of fungus‐specific T cells have been successfully applied. Here we discuss the incidence and changing patterns of invasive fungal diseases, clinical evidence supporting the role of T cells in fungal immunity, methods to expand fungus‐specific T cells in the laboratory and considerations surrounding the use of T cells for fungal immunotherapy.Keywords
This publication has 71 references indexed in Scilit:
- Protective antifungal memory CD8+ T cells are maintained in the absence of CD4+ T cell help and cognate antigen in miceJCI Insight, 2012
- A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cellsBlood, 2011
- Invasive fungal infections in acute leukemiaTherapeutic Advances in Hematology, 2011
- Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal CarcinomaJournal of Immunotherapy, 2010
- An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive ImmunotherapyMolecular Therapy, 2010
- Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-Year Analysis of Susceptibilities of Candida Species to Fluconazole and Voriconazole as Determined by CLSI Standardized Disk DiffusionJournal of Clinical Microbiology, 2010
- Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical TriazolesApplied and Environmental Microbiology, 2009
- Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasisThe Journal of Experimental Medicine, 2009
- Safe adoptive transfer of virus‐specific T‐cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantationBritish Journal of Haematology, 2006
- Interpretive Breakpoints for Fluconazole and Candida Revisited: a Blueprint for the Future of Antifungal Susceptibility TestingClinical Microbiology Reviews, 2006