Histamine-Releasing Factor, a New Therapeutic Target in Allergic Diseases
Open Access
- 26 November 2019
- Vol. 8 (12), 1515
- https://doi.org/10.3390/cells8121515
Abstract
Histamine-releasing activities on human basophils have been studied as potential allergy-causing agents for four decades. An IgE-dependent histamine-releasing factor (HRF) was recently shown to interact with a subset of immunoglobulins. Peptides or recombinant proteins that block the interactions between HRF and IgE have emerged as promising anti-allergic therapeutics, as administration of them prevented or ameliorated type 2 inflammation in animal models of allergic diseases such as asthma and food allergy. Basic and clinical studies support the notion that HRF amplifies IgE-mediated activation of mast cells and basophils. We discuss how secreted HRF promotes allergic inflammation in vitro and in vivo complex disease settings.Keywords
Funding Information
- National Institutes of Health (HL124283, AI124734 and AI146042)
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