Mechanisms of induction of adenosine receptor genes and its functional significance
Open Access
- 2 September 2008
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 218 (1), 35-44
- https://doi.org/10.1002/jcp.21579
Abstract
Adenosine is a metabolite generated and released from cells, particularly under injury or stress. It elicits protective or damaging responses via signaling through the adenosine receptors, including the adenylyl cyclase inhibitory A1 and A3, and the adenylyl cyclase stimulatory A2A and A2B. Multiple adenosine receptor types, including stimulatory and inhibitory, can be found in the same cell, suggesting that a careful balance of adenosine receptor expression in a particular cell is necessary for a specific adenosine‐induced response. This balance could be controlled by differential expression of the adenosine receptor genes under different stimuli. Here, we have reviewed an array of studies that have characterized basal or induced expression of the adenosine receptors and common as well as distinct mechanisms of effect, in hopes that ongoing studies on this topic will further elucidate detailed mechanisms of adenosine receptor regulation, leading to potential therapeutic applications. J. Cell. Physiol. 218: 35–44, 2009.Keywords
This publication has 164 references indexed in Scilit:
- The A2b adenosine receptor protects against vascular injuryProceedings of the National Academy of Sciences of the United States of America, 2008
- B‐Myb regulates the A2B adenosine receptor in vascular smooth muscle cellsJournal of Cellular Biochemistry, 2007
- Synergistic Up-Regulation of Vascular Endothelial Growth Factor (VEGF) Expression in Macrophages by Adenosine A2AReceptor Agonists and Endotoxin Involves Transcriptional Regulation via the Hypoxia Response Element in the VEGF PromoterMolecular Biology of the Cell, 2007
- Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activationThe Journal of Experimental Medicine, 2006
- Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid raftsThe Journal of Experimental Medicine, 2006
- A2A adenosine receptor protects tumors from antitumor T cellsProceedings of the National Academy of Sciences, 2006
- A threshold of GATA4 and GATA6 expression is required for cardiovascular developmentProceedings of the National Academy of Sciences, 2006
- Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptorEuropean Journal Of Cancer, 2000
- CD39 as a Caveolar-Associated EctonucleotidaseBiochemical and Biophysical Research Communications, 1999
- Molecular cloning and expression of an adenosine A2b receptor from human brainBiochemical and Biophysical Research Communications, 1992