First isolations in India ofCandida nivariensis, a globally emerging opportunistic pathogen
Open Access
- 1 March 2010
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 48 (2), 416-420
- https://doi.org/10.3109/13693780903114231
Abstract
We randomly screened 363 yeast isolates during 2008 for their ability to form white colonies on CHROM agar Candida medium. Two of these isolates (0.5%) were identified as Candida nivariensis based on detailed phenotypic characterization and DNA sequencing. One was recovered from the sputum of an HIV-positive patient with a pneumonic lesion and the second from the blood of a diabetic with oropharyngeal lesions. Direct DNA sequencing of the D1/D2 region of 28S rRNA gene and/or the internal transcribed spacer (ITS) regions of rDNA confirmed that both of the isolates were C. nivariensis. The carbohydrate assimilation profiles with the ID 32 C and VITEK 2 yeast identification systems revealed only glucose assimilation. In vitro antifungal susceptibility profiles by broth microdilution and Etest methods revealed susceptibility of both isolates to fluconazole, itraconazole, voriconazole, amphotericin B and 5-flucytosine, with low MICs for posaconazole and caspofungin. These results document the occurrence of Candida nivariensis for the first time in India and focus on its potential as an opportunistic human pathogen.Keywords
This publication has 17 references indexed in Scilit:
- Candida nivariensis , an Emerging Pathogenic Fungus with Multidrug Resistance to Antifungal AgentsJournal of Clinical Microbiology, 2008
- Candida nivariensis Isolated from an Indonesian Human Immunodeficiency Virus-Infected Patient Suffering from Oropharyngeal CandidiasisJournal of Clinical Microbiology, 2008
- Catheter-Related Fungemia Due to Fluconazole-Resistant Candida nivariensisJournal of Clinical Microbiology, 2007
- Epidemiology of Invasive Candidiasis: a Persistent Public Health ProblemClinical Microbiology Reviews, 2007
- Current Treatment Strategies for Disseminated CandidiasisClinical Infectious Diseases, 2006
- Candida bracarensis sp. nov., a novel anamorphic yeast species phenotypically similar to Candida glabrataInternational Journal of Systematic and Evolutionary Microbiology, 2006
- Phenotypic and Molecular Characterization of Candida nivariensis sp. nov., a Possible New Opportunistic FungusJournal of Clinical Microbiology, 2005
- Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyondCandida albicansandAspergillus fumigatusJournal of Clinical Microbiology, 2004
- Guidelines for Treatment of CandidiasisClinical Infectious Diseases, 2004
- New and emerging yeast pathogensClinical Microbiology Reviews, 1995