Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles
- 1 December 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 197 (6), 1205-1210
- https://doi.org/10.1152/ajplegacy.1959.197.6.1205
Abstract
A method is described for studying transcapillary diffusion of K42 in isolated perfused muscles of dogs. Blood flow and arteriovenous K42 differences are measured and blood-tissue clearance calculated by the Fick principle. A theoretical relation between blood flow and blood-tissue clearance is developed for a uniform circulation characterized by a constant permeability—surface area product (PS). The experimental observations conform reasonably closely to prediction. However, systematic variation in measured PS product with changes in blood flow and vascular resistance indicate that the capillary circulation is not uniform.Keywords
This publication has 11 references indexed in Scilit:
- Exchangeability of tissue potassium in skeletal muscleAmerican Journal of Physiology-Legacy Content, 1959
- Measurement of Regional Sodium Turnover Rates and Their Application to the Estimation of Regional Blood FlowAmerican Journal of Physiology-Legacy Content, 1957
- Effects of Denervation on the Histochemical Characterization of Skeletal Muscle During GrowthAmerican Journal of Physiology-Legacy Content, 1956
- Effects of Blood Flow on Diffusion Kinetics in Isolated, Perfused Hindlegs of CatsAmerican Journal of Physiology-Legacy Content, 1955
- Potassium Exchange in the Isolated Rat Diaphragm; Effect of Anoxia and ColdAmerican Journal of Physiology-Legacy Content, 1954
- Passage of Molecules Through Capillary WallsPhysiological Reviews, 1953
- Kinetics Concerned With Distribution of Isotopic Water in Isolated Perfused Dog Heart and Skeletal MuscleAmerican Journal of Physiology-Legacy Content, 1952
- ARTIFICIAL KIDNEY FUNCTION: KINETICS OF HEMODIALYSIS 1JCI Insight, 1951
- A TECHNIQUE FOR OBTAINING AND RECORDING ISOMETRIC CONTRACTIONS OF MAMMALIAN SKELETAL MUSCLES IN SITUAmerican Journal of Physiology-Legacy Content, 1932
- STUDIES IN THE METABOLISM OF MUSCLEAmerican Journal of Physiology-Legacy Content, 1927