A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice
- 20 October 2010
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 3 (6), a003111
- https://doi.org/10.1101/cshperspect.a003111
Abstract
For over a century, mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research, in general, and, in particular, experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia, oncogenic viruses, host responses, endocrinology and neoplastic progression. However, lacking formal proof of a human mammary tumor virus, the preeminence of the mouse model faded in the 1980s. Since the late 1980s, genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a new generation of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an “olive branch” while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.Keywords
This publication has 83 references indexed in Scilit:
- Good, bad and reformableNature, 2006
- The transcriptional repressor Snail promotes mammary tumor recurrenceCancer Cell, 2005
- A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary TumorsCancer Research, 2004
- Tumour-educated macrophages promote tumour progression and metastasisNature Reviews Cancer, 2004
- An Invasion-Independent Pathway of Blood-Borne Metastasis: A New Murine Mammary Tumor ModelThe American Journal of Pathology, 2002
- Studies in HistocompatihilityScandinavian Journal of Immunology, 1992
- Lobular Carcinoma In Situ: A Rare Form of Mammary CancerCA: A Cancer Journal for Clinicians, 1982
- Persistent and atypical lobules in the human breast may be precancerousCellular and Molecular Life Sciences, 1976
- Interactions of Separate Types of Cells During Normal and Neoplastic Mammary Gland GrowthJournal of Investigative Dermatology, 1974
- Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X‐linked male lethal genes jp and msdJournal of Experimental Zoology, 1973