Relation of Plasma Thyroid-Stimulating Hormone Levels to Vascular Lesions and Atrophy of the Brain in the Elderly
- 1 September 2006
- journal article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 27 (2), 89-95
- https://doi.org/10.1159/000095244
Abstract
Recent studies suggest that thyroid disease is associated with cardiovascular and peripheral vascular disease. However, little is known about the underlying pathophysiology and the relation with cerebrovascular disease or brain atrophy in the elderly. To determine if plasma thyroid-stimulating hormone (TSH) levels are associated with vascular brain changes and cortical atrophy in the elderly. Community based, cross-sectional study. 268 participants of the Memory and Morbidity in Augsburg Elderly Study, 65-83 years of age and without contraindications for magnetic resonance imaging (MRI) of the brain. The presence of brain lesions and atrophy was determined using a standardized MRI protocol, an established rating scale and a single rater. Plasma TSH levels were assessed using standard laboratory methods. The association between plasma TSH levels and MRI findings was analyzed using logistic and linear regression models. Higher TSH levels within the normal clinical range were significantly associated with severer cortical atrophy (p = 0.04) and a higher proportion of infarct-like vascular lesions (p = 0.005) in men. These associations were independent of potential confounders, including thyroid hormone therapy, in multivariable regression analysis. No association between plasma TSH levels and both MRI outcomes were observed in women. In addition, neither in men nor in women was an association between TSH levels and white-matter lesions found. Increasing TSH levels even within the normal clinical range are associated with severer brain atrophy and infarct-like vascular lesions in elderly men.Keywords
This publication has 26 references indexed in Scilit:
- Risk for Ischemic Heart Disease and All-Cause Mortality in Subclinical HypothyroidismJournal of Clinical Endocrinology & Metabolism, 2004
- Functional and Cognitive Consequences of Silent Stroke Discovered Using Brain Magnetic Resonance Imaging in an Elderly PopulationJournal of the American Geriatrics Society, 2004
- Low thyroid-stimulating hormone as an independent risk factor for Alzheimer diseaseNeurology, 2004
- Imaging cerebral atrophy: normal ageing to Alzheimer's diseaseThe Lancet, 2004
- Thyroid Dysfunction and Their Relation to Cardiovascular Risk Factors such as Lipid Profile, hsCRP, and Waist Hip Ratio in KoreaThe Korean Journal of Internal Medicine, 2003
- Thyroid Hormone and the Cardiovascular SystemNew England Journal of Medicine, 2001
- CASCADE: A European Collaborative Study on Vascular Determinants of Brain LesionsNeuroepidemiology, 2000
- Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany Results from the MONICA Augsburg cohort study 1984–1992European Heart Journal, 1998
- Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injuryNeuroscience, 1997
- Association between dementia and elevated TSH: A community-based studyBiological Psychiatry, 1996