Teratogenesis and Antiepileptic Drugs

Abstract

The article by Monson et al. (page 1049, this issue) is most thought provoking, but the reader gets the impression that only the very tip of an iceberg has been uncovered. Their series of 50,951 infants was gleaned from the Collaborative Study on Cerebral Palsy, Mental Retardation and Other Neurological and Sensory Disorders of Infancy and Childhood. From this series five groups of infants were identified: infants exposed to diphenylhydantoin during the first four lunar months of gestation; those with sporadic exposure during the first four lunar months; those exposed after four months' gestation; those born to patients with seizures . . .