Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum.
- 1 March 1992
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 23 (3), 328-332
- https://doi.org/10.1161/01.str.23.3.328
Abstract
In rats, degeneration of the ipsilateral substantia nigra occurs a few weeks after occlusion of the middle cerebral artery. The aim of this study was to clarify whether similar change is observed in stroke patients. Eighteen patients with striatal infarction and six patients with cortical infarction in the territory of the middle cerebral artery were examined by means of sequential magnetic resonance imaging. In all patients with striatal infarction, T2-weighted images revealed a high-signal-intensity spot in the ipsilateral substantia nigra. Changes in the ipsilateral substantial nigra appeared at day 14 after stroke on average and then became less intense and smaller a few months after the stroke. By contrast, we observed no nigral changes in any patient with cortical infarction. The degenerative change in the ipsilateral substantia nigra initially found in the rat model similarly occurred in patients with striatal infarction. This remote change in the substantia nigra may represent magnetic resonance imaging detection of neuropathologic changes in this region through the striatonigral pathway.Keywords
This publication has 7 references indexed in Scilit:
- Time-sequential change of amino acid neurotransmitters - GABA, aspartate and glutamate - in the rat basal ganglia following middle cerebral artery occlusionNeurological Research, 1990
- Atrophy of the ipsilateral substantia nigra following middle cerebral artery occlusion in the ratBrain Research, 1990
- Neuronal network disturbance after focal ischemia in rats.Stroke, 1989
- Wallerian degeneration: evaluation with MR imaging.Radiology, 1988
- Reaction of the substantia nigra to massive basal ganglia infarctionActa Neuropathologica, 1983
- Nigrofugal connections in the primate brainJournal of Comparative Neurology, 1970
- An experimental investigation of the connections between the corpus striatum and substantia nigra in the catJournal of Comparative Neurology, 1944