Blood type and outcomes in patients with COVID-19
- 1 September 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Annals of Hematology
- Vol. 99 (9), 2113-2118
- https://doi.org/10.1007/s00277-020-04169-1
Abstract
This study aimed to determine if there is an association between ABO blood type and severity of COVID-19 defined by intubation or death as well as ascertain if there is variability in testing positive for COVID-19 between blood types. In a multi-institutional study, all adult patients who tested positive for COVID-19 across five hospitals were identified and included from March 6th to April 16th, 2020. Hospitalization, intubation, and death were evaluated for association with blood type. Univariate analysis was conducted using standard techniques and logistic regression was used to determine the independent effect of blood type on intubation and/or death and positive testing. During the study period, there were 7648 patients who received COVID-19 testing throughout the institutions. Of these, 1289 tested positive with a known blood type. A total of 484 (37.5%) were admitted to hospital, 123 (9.5%) were admitted to the ICU, 108 (8.4%) were intubated, 3 (0.2%) required ECMO, and 89 (6.9%) died. Of the 1289 patients who tested positive, 440 (34.2%) were blood type A, 201 (15.6%) were blood type B, 61 (4.7%) were blood type AB, and 587 (45.5%) were blood type O. On univariate analysis, there was no association between blood type and any of the peak inflammatory markers (peak WBC,p = 0.25; peak LDH,p = 0.40; peak ESR,p = 0.16; peak CRP,p = 0.14) nor between blood type and any of the clinical outcomes of severity (admissionp = 0.20, ICU admissionp = 0.94, intubationp = 0.93, proning while intubatedp = 0.58, ECMOp = 0.09, and deathp = 0.49). After multivariable analysis, blood type was not independently associated with risk of intubation or death (referent blood type A; blood type B: AOR: 0.72, 95% CI: 0.42-1.26, blood type AB: AOR: 0.78, CI: 0.33-1.87, blood type O: AOR: 0.77, CI: 0.51-1.16), rhesus factor positive (Rh+): AOR: 1.03, CI: 0.93-1.86. Blood type A had no correlation with positive testing (AOR: 1.00, CI: 0.88-1.13), blood type B was associated with higher odds of testing positive for disease (AOR: 1.28, CI: 1.08-1.52), AB was also associated with higher odds of testing positive (AOR: 1.37, CI: 1.02-1.83), and O was associated with a lower risk of testing positive (AOR: 0.84, CI: 0.75-0.95). Rh+ status was associated with higher odds of testing positive (AOR: 1.23, CI: 1.003-1.50). Blood type was not associated with risk of intubation or death in patients with COVID-19. Patients with blood types B and AB who received a test were more likely to test positive and blood type O was less likely to test positive. Rh+ patients were more likely to test positive.Keywords
This publication has 22 references indexed in Scilit:
- Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside WuhanCritical Care, 2020
- Relationship between the ABO Blood Group and the COVID-19 SusceptibilityPublished by Cold Spring Harbor Laboratory ,2020
- Characteristics of COVID-19 infection in BeijingJournal of Infection, 2020
- The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreakJournal of Autoimmunity, 2020
- Frequencies and ethnic distribution of ABO and RhD blood groups in China: a population-based cross-sectional studyBMJ Open, 2017
- Cholera and ABO Blood Group: Understanding an Ancient AssociationThe American Journal of Tropical Medicine and Hygiene, 2016
- Beyond immunohaematology: the role of the ABO blood group in human diseases2013
- ABO Blood Group Phenotypes and Plasmodium falciparum Malaria: Unlocking a Pivotal MechanismAdvances in Parasitology, 2007
- ABO Blood Group and Susceptibility to Severe Acute Respiratory SyndromeJama-Journal Of The American Medical Association, 2005
- Human susceptibility and resistance to Norwalk virus infectionNature Medicine, 2003