Relation of Protease Inhibitor Phenotypes to Obstructive Lung Diseases in a Community
- 26 May 1977
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 296 (21), 1190-1194
- https://doi.org/10.1056/nejm197705262962102
Abstract
To examine the relative risk for the development of obstructive lung disease in persons heterozygous for alpha1-antitrypsin deficiency, we determined protease inhibitor phenotypes in 2944 subjects in a general community population. Phenotype M was found in 89.5 per cent, MS in 7.1 per cent, and MZ in 3.0 per cent of the population. There were two persons of phenotype Z and six of phenotype SZ. The study also included respiratory questionnaires and spirometry. There were no statistically significant differences in the prevalence of respiratory symptoms and diagnoses or of ventilatory impairment among the three major phenotype groups (M, MS and MZ), nor were there differences in the rates of deterioration of function with age or smoking. Consequently, we do not consider population screening for heterozygous alpha1-antitrypsin deficiency to be worthwhile. N Engl J Med 296:1190–1194, 1977)This publication has 23 references indexed in Scilit:
- Physiological studies in a large sibship with antitrypsin deficiencyRespiratory Medicine, 1975
- A Community Study of the Relation of Alpha1-Antitrypsin Levels to Obstructive Lung DiseasesNew England Journal of Medicine, 1975
- Antitrypsin Deficiency and Abnormal Protease Inhibitor PhenotypesArchives of environmental health, 1973
- Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha1 antitrypsinAmerican Journal Of Medicine, 1973
- The Mechanical Properties of the Lungs in Intermediate Deficiency of α1-Antitrypsin1,2American Review of Respiratory Disease, 1972
- Smoking and Chronic Obstructive Lung Disease in Alpha1-Antitrypsin DeficiencyChest, 1971
- Obstructive Lung Disease and α 1 -Antitrypsin Deficiency Gene HeterozygosityScience, 1969
- SERU Pi TYPES IN PATIENTS WITH PULMONARY DISEASESAllergy, 1969
- Pulmonary Emphysema and Alpha1‐Antitrypsin DeficiencyActa Medica Scandinavica, 1964
- The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1963