Purinergic and Vanilloid Receptor Activation Releases Glutamate from Separate Cranial Afferent Terminals in Nucleus Tractus Solitarius
Open Access
- 19 May 2004
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 24 (20), 4709-4717
- https://doi.org/10.1523/jneurosci.0753-04.2004
Abstract
Activation of group 1 metabotropic glutamate receptors (mGluRs) induces long-term depression (LTD) of synaptic transmission that relies on dendritic protein synthesis. We investigated the signal transduction pathways required for mGluR-LTD to identify candidate mechanisms for mGluR regulation of synaptic protein synthesis. Our results demonstrate a role for extracellular signal-regulated protein kinase (ERK), a subclass of the mitogen-activated protein kinases (MAPKs), in mGluR-LTD in area CA1 of the rat hippocampus. Inhibitors of the upstream kinase of ERK, MAP/ERK kinase significantly reduce mGluR-LTD induced by the group 1 agonist dihydroxyphenylglycine (DHPG) and synaptic stimulation but do not affect NMDA receptor-dependent LTD. In contrast, inhibitors of p38 MAPK were ineffective against DHPG-induced LTD. Consistent with the role of ERK in mGluR-LTD, we observed that DHPG treatment of hippocampal slices (isolated CA1), at concentrations that induce LTD, results in a robust phosphorylation of ERK but not of p38 MAPK. These results point to ERK as an important regulator of mGluR-LTD and a potential mechanism for mGluR regulation of synaptic protein synthesis.Keywords
This publication has 50 references indexed in Scilit:
- Distinct Roles of P2X Receptors in Modulating Glutamate Release at Different Primary Sensory Synapses in Rat Spinal CordJournal of Neurophysiology, 2003
- TNP-ATP-Resistant P2X Ionic Current on the Central Terminals and Somata of Rat Primary Sensory NeuronsJournal of Neurophysiology, 2003
- Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in ratThe Journal of Physiology, 2003
- The Vanilloid Receptor: A Molecular Gateway to the Pain PathwayAnnual Review of Neuroscience, 2001
- Pharmacology of Cloned P2X ReceptorsAnnual Review of Pharmacology and Toxicology, 2000
- The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing StimuliNeuron, 1998
- Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neuronesThe Journal of Physiology, 1998
- The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neuronesThe Journal of Physiology, 1998
- Nucleus Tractus Solitarius—Gateway to Neural Circulatory ControlAnnual Review of Physiology, 1994
- Nystatin Perforated Patch Recording and Its Applications to Analyses of Intracellular Mechanisms.The Japanese Journal of Physiology, 1994