On Inventing Reactions for Atom Economy
Top Cited Papers
- 8 March 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 35 (9), 695-705
- https://doi.org/10.1021/ar010068z
Abstract
An important first step in making organic reactions more environmentally benign by design requires processes that are, to a first approximation, simple additions with anything else needed only catalytically. Since so few of the existing reactions are additions, synthesis of complex molecules requires the development of new atom-economic methodology. The prospect for such developments is probed in the context of ruthenium-catalyzed reactions. Using mechanistic reasoning, over 20 new processes of varying complexity have been designed and implemented. While some involved oxidation−reduction processes, most involved C−C bond-forming reactions.Keywords
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