A20 Is Dynamically Regulated in the Heart and Inhibits the Hypertrophic Response
- 12 August 2003
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 108 (6), 664-667
- https://doi.org/10.1161/01.cir.0000086978.95976.41
Abstract
Background— Nuclear factor (NF)–κB signaling has been implicated in cardiomyocyte hypertrophy. Here, we determine the cardiac regulation and biological activity of A20, an inhibitor of NF-κB signaling. Methods and Results— Mice were subjected to aortic banding, and A20 expression was examined. A20 mRNA upregulation (4.3±1.5-fold; P P Conclusions— A20 is dynamically regulated during acute biomechanical stress in the heart and functions to attenuate cardiac hypertrophy through the inhibition of NF-κB signaling without sensitizing cardiomyocytes to apoptotic cell death.Keywords
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