Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1
- 1 May 2009
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 324 (5927), 654-657
- https://doi.org/10.1126/science.1170803
Abstract
Circadian Oscillations: The 24-hour day-night cycle plays an important role in mammalian physiology and behavior and, as most travelers are well aware, there is an intimate link between our in-built circadian clocks and metabolic rhythms. This link is in part forged by the protein deacetylase SIRT1, which regulates the clock's molecular circuitry. SIRT1 uses as a cofactor the cellular metabolite NAD + , which is synthesized through a salvage pathway that includes the enzyme nicotinamide phosphoribosyltransferase (NAMPT) (see the Perspective by Wijnen ). Ramsey et al. (p. 651 ; published online 19 March) and Nakahata et al. (p. 654 , published online 12 March) now show that NAMPT and NAD + levels oscillate during the daily 24-hour cycle and that this oscillation is regulated by the circadian clock. Furthermore, the oscillations in NAD + modulate the activity of SIRT1 feeding back into the circadian clock.Keywords
This publication has 25 references indexed in Scilit:
- Physiological significance of a peripheral tissue circadian clockProceedings of the National Academy of Sciences of the United States of America, 2008
- The Meter of MetabolismCell, 2008
- SIRT1 Is a Circadian Deacetylase for Core Clock ComponentsCell, 2008
- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian ControlCell, 2008
- SIRT1 Regulates Circadian Clock Gene Expression through PER2 DeacetylationCell, 2008
- Anticancer agent CHS-828 inhibits cellular synthesis of NADBiochemical and Biophysical Research Communications, 2008
- Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic EnzymeCell Metabolism, 2007
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell SurvivalCell, 2007
- Circadian Regulator CLOCK Is a Histone AcetyltransferaseCell, 2006
- Calorie restriction, SIRT1 and metabolism: understanding longevityNature Reviews Molecular Cell Biology, 2005