Interleukin‐8 receptor‐mediated chemotaxis of normal human epidermal cells
- 6 July 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 305 (3), 241-243
- https://doi.org/10.1016/0014-5793(92)80677-9
Abstract
Normal human keratinocytes show chemotactic behavior towards interleukin‐8 (IL‐8). Under physiological conditions this cylokine seems to be present in an equilibrium between monomeric and dimeric forms, as indicated by Western blotting data. Radioligand binding studies suggest that keratinocyte chemotaxis is mediated by receptors specific for IL‐8 dimers. IL‐8 rcceptor‐specific mRNA can be detected in a keratinocyte cell line by polymerase chain reaction.Keywords
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