Aberrant angiogenesis: The gateway to diabetic complications
Open Access
- 1 January 2012
- journal article
- review article
- Published by Medknow in Indian Journal of Endocrinology and Metabolism
- Vol. 16 (6), 918-930
- https://doi.org/10.4103/2230-8210.102992
Abstract
Diabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribute toward many of the clinical manifestations of diabetes. These are implicated in the pathogenesis of vascular abnormalities of the retina, kidneys, and fetus, impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. The current article hereby reviews the molecular mechanisms including abnormalities in growth factors, cytokines, and metabolic derangements, clinical implications, and therapeutic options of dealing with abnormal angiogenesis in diabetes.Keywords
This publication has 90 references indexed in Scilit:
- Roles of Angiopoietins in Kidney Development and DiseaseJournal of the American Society of Nephrology, 2009
- VEGF-A splicing: the key to anti-angiogenic therapeutics?Nature Reviews Cancer, 2008
- Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived CellsThe American Journal of Pathology, 2004
- The effect of streptozotocin-induced experimental diabetes mellitus on calvarial defect healing and bone turnover in the ratInternational Journal of Oral & Maxillofacial Surgery, 2001
- Multifactorial basis of the syndrome of diabetic embryopathyTeratology, 1996
- Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic RabbitsBiochemical and Biophysical Research Communications, 1996
- Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β 1Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
- Coronary artery disease and coronary artery bypass grafting in diabetic patients aged ≥65 years (report from the Coronary Artery Surgery Study [CASS] registry)The American Journal of Cardiology, 1994
- Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.JCI Insight, 1993
- New vessel formation in the renal corpuscles in advanced diabetic glomerulopathyJournal of Diabetic Complications, 1987