Inactivation of Enteric Adenovirus and Feline Calicivirus by Chlorine Dioxide

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Abstract
Chlorine dioxide (ClO 2 ) inactivation experiments were conducted with adenovirus type 40 (AD40) and feline calicivirus (FCV). Experiments were carried out in buffered, disinfectant demand-free water under high- and low-pH and -temperature conditions. Ct values (the concentration of ClO 2 multiplied by contact time with the virus) were calculated directly from bench-scale experiments and from application of the efficiency factor Hom (EFH) model. AD40 Ct ranges for 4-log inactivation ( Ct 99.99% ) at 5°C were >0.77 to 0.80 to 0.49 to Ct 99.99% ranges were >4.20 to Ct values and inactivation curves demonstrated that the EFH model described bench-scale experiment data very well. Observed bench-scale Ct 99.99% ranges and EFH model Ct 99.99% values demonstrated that FCV is more resistant to ClO 2 than AD40 for the conditions studied. U.S. Environmental Protection Agency guidance manual Ct 99.99% values are higher than Ct 99.99% values calculated from bench-scale experiments and from EFH model application.