Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by Ethanol
- 8 November 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3854), 690-691
- https://doi.org/10.1126/science.162.3854.690
Abstract
The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.Keywords
This publication has 5 references indexed in Scilit:
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- Alcohol-Induced Hepatic Injury in Nonalcoholic VolunteersNew England Journal of Medicine, 1968
- Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing EnzymesScience, 1968
- Activation and inhibition of microsomal hydroxylation by ethyl isocyanideBiochemical and Biophysical Research Communications, 1966
- Wechselwirkungen zwischen Alkohol und ArzneimittelnDeutsche Medizinische Wochenschrift (1946), 1966