BMGE (Block Mapping and Gathering with Entropy): a new software for selection of phylogenetic informative regions from multiple sequence alignments
Top Cited Papers
Open Access
- 1 January 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Evolutionary Biology
- Vol. 10 (1), 210
- https://doi.org/10.1186/1471-2148-10-210
Abstract
The quality of multiple sequence alignments plays an important role in the accuracy of phylogenetic inference. It has been shown that removing ambiguously aligned regions, but also other sources of bias such as highly variable (saturated) characters, can improve the overall performance of many phylogenetic reconstruction methods. A current scientific trend is to build phylogenetic trees from a large number of sequence datasets (semi-)automatically extracted from numerous complete genomes. Because these approaches do not allow a precise manual curation of each dataset, there exists a real need for efficient bioinformatic tools dedicated to this alignment character trimming step.Keywords
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