p-TOLUENESULFONIC ACID-CATALYZED EFFICIENT SYNTHESIS OF DIHYDROPYRIMIDINES: IMPROVED HIGH YIELDING PROTOCOL FOR THE BIGINELLI REACTION
- 1 January 2002
- journal article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 32 (12), 1847-1851
- https://doi.org/10.1081/scc-120004068
Abstract
Dihydropyrimidines are prepared by a one-pot cyclocondensation of aldehydes, β-ketoesters and urea with p-toluenesulfonic acid-catalyzed condensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.Keywords
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