Role of the vitamin D‐endocrine system in the pathophysiology of postmenopausal osteoporosis
- 6 January 2003
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 88 (2), 209-215
- https://doi.org/10.1002/jcb.10345
Abstract
Impaired calcium absorption and impaired adaptation to a low calcium diet are common features of aging in women and these processes are even more severely impaired in patients with osteoporotic fractures. The calcium absorption defects are associated with several abnormalities of the vitamin D‐endocrine system including secondary hyperparathyroidism, intestinal resistance to 1,25‐dihydroxyvitamin D (1,25(OH)2D) action, decreased 1,25(OH)2D production due to impaired 25(OH)D 1α‐hydroxylase activity, and, in some elderly persons, nutritional deficiency of vitamin D. However, in postmenopausal women, most of these abnormalities are normalized by administration of physiologic replacement dosages of estrogen and, thus, appear to be secondary consequences of estrogen deficiency. Nonetheless, a minority of them, especially nutritional vitamin D deficiency and impaired 25(OH)D 1α‐hydroxylase activity late in life, appear to be primary and are independent of estrogen deficiency. J. Cell. Biochem. 88: 209–215, 2003.Funding Information
- National Institutes of Health (P01 AG04875)
- United States Public Health Service
This publication has 36 references indexed in Scilit:
- Relationship of Serum Sex Steroid Levels and Bone Turnover Markers with Bone Mineral Density in Men and Women: A Key Role for Bioavailable EstrogenJournal of Clinical Endocrinology & Metabolism, 1998
- 1-α-Hydroxyvitamin D3 treatment decreases bone turnover and modulates calcium-regulating hormones in early postmenopausal womenBone, 1997
- Association Between Intestinal Vitamin D Receptor, Calcium Absorption, and Serum 1,25 Dihydroxyvitamin D in Normal Young and Elderly WomenJournal of Bone and Mineral Research, 1997
- Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal womenJournal of Bone and Mineral Research, 1996
- Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause--a clinical research center studyJournal of Clinical Endocrinology & Metabolism, 1995
- Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3Journal of Clinical Endocrinology & Metabolism, 1994
- Treatment of Postmenopausal Osteoporosis with Calcitriol or CalciumThe New England Journal of Medicine, 1992
- Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.JCI Insight, 1981
- Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic PatientsJCI Insight, 1979
- Effect of Dietary Calcium and Age on Jejunal Calcium Absorption in Humans Studied by Intestinal PerfusionJCI Insight, 1973