Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation
Open Access
- 8 August 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Ocular Biology, Diseases, and Informatics
- Vol. 1 (2-4), 94-100
- https://doi.org/10.1007/s12177-008-9010-6
Abstract
The eye, like the brain and reproductive organs, possesses inherent immune privilege, and inflammation is self-regulated so as to preserve the organ functions. Studies over the past 30 years have provided insights of the multiple mechanisms of immune privilege. At present, three major lines of thought prevail regarding the molecular mechanisms of immune privilege in the eye: there are (1) anatomical, cellular, and molecular barriers in the eye; (2) eye-derived immunological tolerance, the so-called anterior chamber-associated immune deviation; and (3) immune suppressive intraocular microenvironment. In this review, the mechanisms of immune privilege that have been learned from ocular inflammation animal models, especially corneal transplantation, are described. Roles of new B7 family molecules on local immune regulation within the cornea are also introduced.Keywords
This publication has 46 references indexed in Scilit:
- See no evil, hear no evil, do no evil: the lessons of immune privilegeNature Immunology, 2006
- Splenic B Cells Act as Antigen Presenting Cells for the Induction of Anterior Chamber-Associated Immune DeviationInvestigative Ophthalmology & Visual Science, 2003
- CD25+, interleukin‐10‐producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eyeImmunology, 2003
- Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte–associated Antigen 4The Journal of Experimental Medicine, 2003
- Thrombospondin-1, a Natural Inhibitor of Angiogenesis, Is Present in Vitreous and Aqueous Humor and Is Modulated by HyperglycemiaBiochemical and Biophysical Research Communications, 2000
- Fas Ligand-Induced Apoptosis as a Mechanism of Immune PrivilegeScience, 1995
- Novel production of interleukin-1 receptor antagonist peptides in normal human cornea.JCI Insight, 1995
- ORTHOTOPIC CORNEAL TRANSPLANTATION IN MICE—EVIDENCE THAT THE IMMUNOGENETIC RULES OF REJECTION DO NOT APPLYTransplantation, 1992
- Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐βEuropean Journal of Immunology, 1992
- Use of ACAID to suppress interphotoreceptor retinoid binding protein-induced experimental autoimmune uveitisCurrent Eye Research, 1992