MRI Profile of the Perihematomal Region in Acute Intracerebral Hemorrhage
- 1 November 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 41 (11), 2681-2683
- https://doi.org/10.1161/strokeaha.110.590638
Abstract
Background and Purpose— The pathophysiology of the presumed perihematomal edema immediately surrounding an acute intracerebral hemorrhage is poorly understood, and its composition may influence clinical outcome. Method— Twenty-three patients from the Diagnostic Accuracy of MRI in Spontaneous intracerebral Hemorrhage (DASH) study were prospectively enrolled and studied with MRI. Perfusion-weighted imaging, diffusion-weighted imaging, and fluid-attenuated inversion recovery sequences were coregistered. TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient values in the presumed perihematomal edema regions of interest were compared with contralateral mirror and remote ipsilateral hemispheric regions of interest. Results— Compared with mirror and ipsilateral hemispheric regions of interest, TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient were consistently increased in the presumed perihematomal edema. Two thirds of the patients also exhibited patchy regions of restricted diffusion in the presumed perihematomal edema. Conclusion— The MRI profile of the presumed perihematomal edema in acute intracerebral hemorrhage exhibits delayed perfusion and increased diffusivity mixed with areas of reduced diffusion.Keywords
This publication has 10 references indexed in Scilit:
- Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patientsNeurology, 2009
- Perfusion mapping with multiecho multishot parallel imaging EPIMagnetic Resonance in Medicine, 2007
- Perfusion-Weighted Magnetic Resonance Imaging in Acute Intracerebral Hemorrhage at Baseline and during the 1st and 2nd Week: A Longitudinal StudyCerebrovascular Diseases, 2006
- Mechanisms of brain injury after intracerebral haemorrhageThe Lancet Neurology, 2006
- Perihematomal Edema in Primary Intracerebral Hemorrhage Is Plasma DerivedStroke, 2004
- Stroke MRI in Intracerebral HemorrhageStroke, 2003
- Brain Edema After Human Cerebral Hemorrhage A Magnetic Resonance Imaging Volumetric AnalysisJournal of Neurosurgical Anesthesiology, 2003
- Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage.Stroke, 2002
- Human Brain Hemorrhage: Quantification of Perihematoma Edema by Use of Diffusion-Weighted MR Imaging2002
- Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhageNeurology, 2001