Nurses working in general practice (GP) settings are generally multi-skilled and competent practitioners who come into contact with a huge cross-section of patients. These patients frequently present with a combination of health problems/needs. The practice nurse is often the first person with whom the patient comes into contact and/or consults. Practice nurses therefore have an important role to play in promoting health, including sexual health. This article examines the conclusions of Jewitt's (1995) work which explored the development of sexual history taking in GP settings. The pivotal role of the practice nurse is highlighted and the importance of taking a sexual health history is discussed. The obstacles and barriers faced by practice nurses when taking a sexual health history are outlined. Recommendations for practice are discussed, and a check list is presented that will enable practice nurses to consider their invaluable input into the holistic care of patients in more detail.