Marine Antitumor Drugs: Status, Shortfalls and Strategies
Open Access
- 15 October 2010
- journal article
- review article
- Published by MDPI AG in Marine Drugs
- Vol. 8 (10), 2702-2720
- https://doi.org/10.3390/md8102702
Abstract
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.Keywords
This publication has 84 references indexed in Scilit:
- Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine ActinomyceteOrganic Letters, 2009
- Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of actionBiochimica et Biophysica Acta (BBA) - General Subjects, 2009
- Marine natural products as inhibitors of hypoxic signaling in tumorsPhytochemistry Reviews, 2009
- Arenamides A−C, Cytotoxic NFκB Inhibitors from the Marine Actinomycete Salinispora arenicolaJournal of Natural Products, 2008
- Molecular-Targeted Antitumor Agents. 19. Furospongolide from a Marine Lendenfeldia sp. Sponge Inhibits Hypoxia-Inducible Factor-1 Activation in Breast Tumor CellsJournal of Natural Products, 2008
- Metalloproteinases and their inhibitors: Regulators of wound healingThe International Journal of Biochemistry & Cell Biology, 2008
- Total Synthesis and Absolute Configuration of Laurenditerpenol: A Hypoxia Inducible Factor-1 Activation InhibitorJournal of Medicinal Chemistry, 2007
- Molecular-Targeted Antitumor Agents. 15. Neolamellarins from the Marine Sponge Dendrilla nigra Inhibit Hypoxia-Inducible Factor-1 Activation and Secreted Vascular Endothelial Growth Factor Production in Breast Tumor CellsJournal of Natural Products, 2007
- Benzochromenones from the Marine Crinoid Comantheria rotula Inhibit Hypoxia-Inducible Factor-1 (HIF-1) in Cell-Based Reporter Assays and Differentially Suppress the Growth of Certain Tumor Cell LinesJournal of Natural Products, 2007
- Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus SalinosporaAngewandte Chemie, 2003