Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
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Open Access
- 1 July 2015
- journal article
- research article
- Published by Elsevier BV in Cell
- Vol. 162 (3), 552-563
- https://doi.org/10.1016/j.cell.2015.07.017
Abstract
No abstract availableKeywords
This publication has 53 references indexed in Scilit:
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug PhenforminCancer Cell, 2013
- Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMolecular Systems Biology, 2013
- Reductive carboxylation supports growth in tumour cells with defective mitochondriaNature, 2011
- Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent BiosensorCell Metabolism, 2011
- Assessing mitochondrial dysfunction in cellsBiochemical Journal, 2011
- NAD+ as a Signaling Molecule Modulating MetabolismCold Spring Harbor Symposia on Quantitative Biology, 2011
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityProceedings of the National Academy of Sciences of the United States of America, 2010
- A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosisHuman Molecular Genetics, 2009
- The impact of O2 availability on human cancerNature Reviews Cancer, 2008
- Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesisProceedings of the National Academy of Sciences of the United States of America, 2007