Cytokine changes after a marathon race
- 1 July 2001
- journal article
- clinical trial
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 91 (1), 109-114
- https://doi.org/10.1152/jappl.2001.91.1.109
Abstract
The influence of carbohydrate (1 l/h of a 6% carbohydrate beverage), gender, and age on pro- and anti-inflammatory plasma cytokine and hormone changes was studied in 98 runners for 1.5 h after two competitive marathon races. The marathoner runners were randomly assigned to carbohydrate (C, n = 48) and placebo (P, n = 50) groups, with beverages administered during the races in a double-blind fashion using color codes. Plasma glucose was higher and cortisol was lower in the C than in the P group after the race (P < 0.001). For all subjects combined, plasma levels of interleukin (IL)-10, IL-1 receptor antagonist (IL-1ra), IL-6, and IL-8 rose significantly immediately after the race and remained above prerace levels 1.5 h later. The pattern of change in all cytokines did not differ significantly between the 12 women and 86 men in the study and the 23 subjects ≥50 yr of age and the 75 subjects <50 yr of age. The pattern of change in IL-10, IL-1ra, and IL-8, but not IL-6, differed significantly between the C and the P group, with higher postrace values measured for IL-10 (109% higher) and IL-1ra (212%) in the P group and for IL-8 (42%) in the C group. In conclusion, plasma levels of IL-10, IL-1ra, IL-6, and IL-8 rose strongly in runners after a competitive marathon, and this was not influenced by age or gender. Carbohydrate ingestion, however, had a major effect in attenuating increases in cortisol and two anti-inflammatory cytokines, IL-10 and IL-1ra.Keywords
This publication has 31 references indexed in Scilit:
- The Acute Response of the Immune System to Tennis Drills in Adolescent AthletesResearch Quarterly for Exercise and Sport, 2000
- Influence of Vitamin C Supplementation on Cytokine Changes Following an UltramarathonJournal of Interferon & Cytokine Research, 2000
- Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humansThe Journal of Physiology, 1999
- Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged runningThe Journal of Physiology, 1998
- Aging and immune response to exerciseCanadian Journal of Physiology and Pharmacology, 1998
- Blood Mononudear Cells Mobilization and Cytokines Secretion During Prolonged ExercisesInternational Journal of Sports Medicine, 1996
- Hormonal and Metabolite Responses to Glucose and Maltodextrin Ingestion With or Without the Addition of Guar GumInternational Journal of Sports Medicine, 1994
- The Cytokine Response to Strenuous ExerciseInternational Journal of Sports Medicine, 1994