Maternal Microbe-Specific Modulation of Inflammatory Response in Extremely Low-Gestational-Age Newborns
Open Access
- 1 March 2011
- journal article
- Published by American Society for Microbiology in mBio
- Vol. 2 (1), e00280-10
- https://doi.org/10.1128/mbio.00280-10
Abstract
The fetal response to intrauterine inflammatory stimuli appears to contribute to the onset of preterm labor as well as fetal injury, especially affecting newborns of extremely low gestational age. To investigate the role of placental colonization by specific groups of microorganisms in the development of inflammatory responses present at birth, we analyzed 25 protein biomarkers in dry blood spots obtained from 527 newborns delivered by Caesarean section in the 23rd to 27th gestation weeks. Bacteria were detected in placentas and characterized by culture techniques. Odds ratios for having protein concentrations in the top quartile for gestation age for individual and groups of microorganisms were calculated. Mixed bacterial vaginosis (BV) organisms were associated with a proinflammatory pattern similar to those of infectious facultative anaerobes. Prevotella and Gardnerella species, anaerobic streptococci, peptostreptococci, and genital mycoplasmas each appeared to be associated with a different pattern of elevated blood levels of inflammation-related proteins. Lactobacillus was associated with low odds of an inflammatory response. This study provides evidence that microorganisms colonizing the placenta provoke distinctive newborn inflammatory responses and that Lactobacillus may suppress these responses.Keywords
This publication has 51 references indexed in Scilit:
- Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulationCytokine, 2011
- The ELGAN study of the brain and related disorders in extremely low gestational age newbornsEarly Human Development, 2009
- Systems biology of innate immunityImmunological Reviews, 2008
- Pregnancy Disorders That Lead to Delivery Before the 28th Week of Gestation: An Epidemiologic Approach to ClassificationAmerican Journal of Epidemiology, 2008
- Colonization of second-trimester placenta parenchymaAmerican Journal of Obstetrics and Gynecology, 2008
- Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter StudyAnalytical Chemistry, 2008
- The Alabama Preterm Birth Study: Umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infantsAmerican Journal of Obstetrics and Gynecology, 2008
- Epidemiology and causes of preterm birthThe Lancet, 2008
- The Human Vaginal Bacterial Biota and Bacterial VaginosisInterdisciplinary Perspectives on Infectious Diseases, 2008
- Epithelial cells prime the immune response to an array of gut‐derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor‐βImmunology, 2007