Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
- 13 September 2005
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 65 (5), 745-747
- https://doi.org/10.1212/01.wnl.0000174432.87383.87
Abstract
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.Keywords
This publication has 8 references indexed in Scilit:
- Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutationBrain, 2002
- Regional and progressive thinning of the cortical ribbon in Huntington’s diseaseNeurology, 2002
- Whole Brain SegmentationNeuron, 2002
- Changes in Cortical and Striatal Neurons Predict Behavioral and Electrophysiological Abnormalities in a Transgenic Murine Model of Huntington's DiseaseJournal of Neuroscience, 2001
- Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's DiseaseScience, 2001
- Huntington DiseaseJournal of Neuropathology and Experimental Neurology, 1998
- Widespread expression of Huntington's disease gene (IT15) protein productNeuron, 1995
- Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsNeuron, 1995